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Literature summary extracted from
- Kallikrein 7 enhances pancreatic cancer cell invasion by shedding E-cadherin (2007), Cancer, 109, 1811-1820.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.21.117 | gene KLK7, expression profiling in BxPC-3 cells from pancreatic adenocarcinomas | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.117 | chymostatin | - |
Homo sapiens |  |
| 3.4.21.117 | additional information | phosphoramidon inhibits thermolysin and thus activation of pro-kallikrein 7 | Homo sapiens |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.117 | Ca2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.117 | E-cadherin + H2O | Homo sapiens | kallikrein 7 degrades extracellular matrix proteins, and enhances pancreatic cancer cell invasion by shedding E-cadherin, overview | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.117 | Homo sapiens | - |
gene KLK7 | - |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.21.117 | proteolytic modification | activation of recombinant pro-kallikrein 7 by thermolysin, inhibited by phosphoramidon | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.117 | BxPC-3 cell | - |
Homo sapiens | - |
| 3.4.21.117 | commercial preparation | recombinant pro-kallikrein 7 | Homo sapiens | - |
| 3.4.21.117 | PANC-1 cell | - |
Homo sapiens | - |
| 3.4.21.117 | pancreatic cancer cell | PCR expression profile of serine proteases from both healthy and malignant pancreatic tissues | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.117 | additional information | - |
cell aggregation assay using Panc-1 cells | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.117 | E-cadherin + H2O | kallikrein 7 degrades extracellular matrix proteins, and enhances pancreatic cancer cell invasion by shedding E-cadherin, overview | Homo sapiens | ? | - |
? | |
| 3.4.21.117 | E-cadherin + H2O | epithelial cell adhesion molecule | Homo sapiens | ? | - |
? | |
| 3.4.21.117 | Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 + H2O | a fluorogenic peptide substrate | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.117 | kallikrein 7 | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.117 | 37 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.117 | 7.5 | 8.5 | assay at | Homo sapiens |
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